With just seven suites in a 14th-century palazzo (four apartments, three B&B), brothers Marco and Alessio Ducceschi have retained the charm of a home-away-from-home. Rooms feature wooden beams, high ceilings and terracotta floors refurbished to 21st-century luxury standards with modern kitchens and crisp linens on beds. Find it on a quiet cobbled street just minutes from Piazza della Signoria. Via delle Terme 6 cantodegliscali.com
This venue features in the NINE chapter of Lost in Florence - the book - with over 150 unique and independent venues to explore in the Renaissance capital.